Canadian Medical Guide > Biological Sciences > Genetic Processes > Gene Expression > Translation, Genetic > Frameshifting, Ribosomal Terms and Definitions

Frameshifting, Ribosomal

Medical Definition:	A directed change in translational READING FRAMES that allows the production of a single protein from two or more OVERLAPPING GENES. The process is programmed by the nucleotide sequence of the MRNA and is sometimes also affected by the secondary or tertiary mRNA structure. It has been described mainly in VIRUSES (especially RETROVIRUSES), RETROTRANSPOSONS, and bacterial insertion elements but also in some cellular genes.
Guide Notes:	do not confuse with FRAMESHIFT MUTATION, non-physiol insertion or deletion of coding sequence nucleotides
Previously Indexed:	Frameshift Mutation (1991-1995),Ribosomes (1979-1995),Translation, Genetic (1979-1995)

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