Canadian Medical Guide > Biological Sciences > Genetic Processes > Gene Expression Regulation > RNA Processing, Post-Transcriptional > RNA 3' End Processing Terms and Definitions




RNA 3' End Processing

Medical Definition: The steps that generate the 3' ends of mature RNA molecules. For most mRNAs (RNA, MESSENGER), 3' end processing referred to as POLYADENYLATION includes the addition of POLY A.
Previously Indexed: RNA Processing, Post-Transcriptional (1984-2001)
RNA 3' End Processing Categories.
Canadian Medical Guide Definition Polyadenylation - The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.

RNA 3' End Processing Medical Definitions and Terms

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