Canadian Medical Guide > Chemicals and Drugs > Nucleic Acids, Nucleotides, and Nucleosides > Antisense Elements (Genetics) > RNA, Antisense > RNA, Small Interfering Terms and Definitions




RNA, Small Interfering

Medical Definition: Small ANTISENSE RNAs (20 -25 nucleotides) that are generated from specific dsRNAs (RNA, DOUBLE-STRANDED) which trigger targeted mRNA (RNA, MESSENGER) degradation (RNA INTERFERENCE). They serve as guides for the cleavage of homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. The same ribonuclease, Dicer, that is required for processing of the dsRNAs to siRNA is also involved in processing MICRORNAS (miRNAs) from their precursor RNAs.
Guide Notes: Do not confuse with defective interfering RNA (diRNA), a viral RNA (RNA, VIRAL) of DEFECTIVE VIRUSES.

RNA, Small Interfering Medical Definitions and Terms

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