Canadian Medical Guide > Biological Sciences > Biochemical Phenomena, Metabolism, and Nutrition > Metabolism > Pharmacokinetics > Tissue Distribution Terms and Definitions

Tissue Distribution

Medical Definition:	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Guide Notes:	distrib of drugs or chem in organs & tissues; GEN only: not a substitute for organ /metab or organ /chem; never IM; coord NIM with substance /pharmacokin (IM) or /metab (IM)
Previously Indexed:	Organ Specificity (1966-1977)

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