Canadian Medical Guide > Biological Sciences > Biochemical Phenomena, Metabolism, and Nutrition > Metabolism > Pharmacokinetics Terms and Definitions




Pharmacokinetics

Medical Definition: Dynamic and kinetic mechanisms of exogenous chemical and drug absorption, biotransformation, distribution, release, transport, uptake, and elimination as a function of dosage, and extent and rate of metabolic processes. It includes toxicokinetics, the pharmacokinetic mechanism of the toxic effects of a substance.
Guide Notes: GEN or unspecified; no qualif; prefer /pharmacokin with drugs: Manual 19.7+, 19.8.53, 19.10+; DF: PHARMACOKIN
Also Called: Toxicokinetics
Previously Indexed: Kinetics (1966-1987),specific Category D heading/metabolism (1966-1987)
Pharmacokinetics Categories.
Canadian Medical Guide Definition Biotransformation - The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alteration may be either non-synthetic (OXIDATION-REDUCTION; HYDROLYSIS) or synthetic (glucuronide formation, sulfate conjugation, ACETYLATION; METHYLATION). This also includes metabolic detoxication and clearance.
Canadian Medical Guide Definition Tissue Distribution - Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Pharmacokinetics Medical Definitions and Terms

CANADIAN MEDICAL GUIDE

Thank you for visiting Canadian Medical Guide .com





Wildlife On Video »

Canadian Medical Guide Canada's Great Outdoors
Tour Canadian Rockies »
Book Banff »
Book Jasper »
Maligne Lake Boat Cruise »
Gondola Banff »
Hike Jasper »
Jasper Columbia Icefield »