Canadian Medical Guide > Diseases > Hemic and Lymphatic Diseases > Hematologic Diseases > Leukocyte Disorders > Phagocyte Bactericidal Dysfunction > Chediak-Higashi Syndrome Terms and Definitions

Chediak-Higashi Syndrome

Medical Definition:	A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.
Guide Notes:	"a form of phagocyte bactericidal dysfunct"
Previously Indexed:	Immunologic Deficiency Syndromes (1968-1970),Leukocytes (1966-1970)

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