Canadian Medical Guide > Analytical, Diagnostic and Therapeutic Techniques and Equipment > Diagnosis > Laboratory Techniques and Procedures > Immunologic Tests > Serologic Tests Terms and Definitions

Serologic Tests

Medical Definition:	Diagnostic procedures involving immunoglobulin reactions.
Guide Notes:	GEN or unspecified; prefer specifics; NIM; Manual 26.9-26.9.2; restrict to determ of immune cpds (e.g., antibodies) in serum: do not confuse with SEROLOGY, the specialty; DF: SERODIAG
Also Called:	Serodiagnosis

Serologic Tests Categories.

	Agglutination Tests - Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
	AIDS Serodiagnosis - Immunologic tests for identification of HIV (HTLV-III/LAV) antibodies. They include assays for HIV SEROPOSITIVITY and HIV SERONEGATIVITY; (ELISA, immunofluorescence, immunoblot, etc.) that have been developed for screening persons carrying the viral antibody from patients with overt symptoms of AIDS or AIDS-RELATED COMPLEX.
	Complement Fixation Tests - Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
	Hemadsorption Inhibition Tests
	Hemagglutination Inhibition Tests - Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.
	Neutralization Tests - Titration of an antiserum by testing a series of dilutions of virus or immune serum to a given end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
	Precipitin Tests - Serologic tests in which a positive reaction manifested by visible precipitation occurs when a soluble antigen reacts with its antibody.
	Syphilis Serodiagnosis - Serologic tests for syphilis.

Serologic Tests Medical Definitions and Terms

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