Canadian Medical Guide > Analytical, Diagnostic and Therapeutic Techniques and Equipment > Diagnosis > Laboratory Techniques and Procedures > Immunologic Tests > Histocompatibility Testing Terms and Definitions




Histocompatibility Testing

Medical Definition: Identification of the major histocompatibility antigens of transplant donors and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for histocompatibility antigens in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Guide Notes: human or animal
Also Called: HLA Typing
Previously Indexed: Transplantation Immunology (1966-1967)
Histocompatibility Testing Categories.
Canadian Medical Guide Definition Lymphocyte Culture Test, Mixed - Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.

Histocompatibility Testing Medical Definitions and Terms

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