Canadian Medical Guide > Biological Sciences > Genetic Processes > Gene Expression Regulation > Gene Silencing > RNA Interference Terms and Definitions




RNA Interference

Medical Definition: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX (RISC). DNA METHYLATION may also be triggered during this process.

RNA Interference Medical Definitions and Terms

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