Canadian Medical Guide > Biological Sciences > Genetic Processes > Gene Expression Regulation > Gene Silencing Terms and Definitions




Gene Silencing

Medical Definition: Interruption or suppression of the expression of a gene at transcriptional or translational levels.
Previously Indexed: Gene Expression Regulation (1981-1999)
Gene Silencing Categories.
Canadian Medical Guide Definition RNA Interference - A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX (RISC). DNA METHYLATION may also be triggered during this process.

Gene Silencing Medical Definitions and Terms

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