Canadian Medical Guide > Biological Sciences > Genetic Processes > Gene Expression Regulation > Protein Processing, Post-Translational Terms and Definitions

Protein Processing, Post-Translational

Medical Definition:	Any of various enzymically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation, HYDROXYLATION, ACETYLATION, PHOSPHORYLATION, METHYLATION, GLYCOSYLATION, ubiquitination, oxidation-reduction, degradation and lysis, peptide bond formation, and changes in molecular weight and electrophoretic motility.
Guide Notes:	coord IM with specific protein /metab (IM); DF: PROTEIN PROC POST
Previously Indexed:	Translation, Genetic (1973-1982)

Protein Processing, Post-Translational Categories.

	Protein Isoprenylation - A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.
	Protein Splicing - Excision of in-frame internal protein sequences (inteins) of a precursor protein, coupled with ligation of the flanking sequences (exteins). Protein splicing is an autocatalytic reaction and results in the production of two proteins from a single primary translation product: the intein and the mature protein.

Protein Processing, Post-Translational Medical Definitions and Terms

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