Canadian Medical Guide > Biological Sciences > Genetic Processes > Mutagenesis > DNA Repeat Expansion > Trinucleotide Repeat Expansion Terms and Definitions




Trinucleotide Repeat Expansion

Medical Definition: An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.
Previously Indexed: Repetitive Sequences, Nucleic Acid (1981-1997)

Trinucleotide Repeat Expansion Medical Definitions and Terms

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