Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Heterocyclic Compounds, 1-Ring > Pyridines > Dihydropyridines Terms and Definitions

Dihydropyridines

Medical Definition:	Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.
Previously Indexed:	Nifedipine/analogs & derivatives (1975-1987),Pyridines (1966-1987)

Dihydropyridines Categories.

	Amlodipine - A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of angina pectoris and hypertension.
	Bay-K-8644 - A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
	Dicarbethoxydihydrocollidine - 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester.
	Felodipine - A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
	Isradipine - A potent antagonist of CALCIUM CHANNELS that is highly selective for vascular smooth muscle. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.
	Nicardipine - A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
	Nifedipine - A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
	Nimodipine - A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
	Nisoldipine - A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.
	Nitrendipine - A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.

Dihydropyridines Medical Definitions and Terms

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