Canadian Medical Guide > Chemicals and Drugs > Central Nervous System Agents > Psychotropic Drugs > Antidepressive Agents Terms and Definitions




Antidepressive Agents

Medical Definition: Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Guide Notes: GEN or unspecified; prefer specific groups or specific antidepressive agents; consider also DEPRESSION /drug ther
Also Called: Thymoanaleptics,Thymoleptics
Antidepressive Agents Categories.
Canadian Medical Guide Definition Antidepressive Agents, Second-Generation - A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
Canadian Medical Guide Definition Antidepressive Agents, Tricyclic - Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.

Antidepressive Agents Medical Definitions and Terms

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