Canadian Medical Guide > Chemicals and Drugs > Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > Nucleic Acid Probes > Oligonucleotide Probes Terms and Definitions

Oligonucleotide Probes

Medical Definition:	Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.
Guide Notes:	usually no qualif; /drug eff /ultrastruct permitted
Also Called:	Oligoribonucleotide Probes,Oligodeoxyribonucleotide Probes
Previously Indexed:	Nucleic Acid Hybridization (1972-1988),Oligonucleotides (1972-1988)

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