Canadian Medical Guide > Chemicals and Drugs > Nucleic Acids, Nucleotides, and Nucleosides > Nucleic Acids > Nucleic Acid Probes > DNA Probes Terms and Definitions




DNA Probes

Medical Definition: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Guide Notes: GEN or unspecified; prefer specifics; /drug eff /ultrastruct permitted; cDNA PROBES see DNA, COMPLEMENTARY is also available
Also Called: Chromosomal Probes,Conserved Gene Probes,Gene Probes, DNA,Whole Chromosomal Probes,Whole Genomic DNA Probes
Previously Indexed: DNA or specific DNA (1972-1988),Nucleic Acid Hybridization (1972-1988)
DNA Probes Categories.
Canadian Medical Guide Definition DNA Probes, HLA - DNA probes specific for the human leukocyte antigen genes, which represent the major histocompatibility determinants in humans. The four known loci are designated as A, B, C, and D. Specific antigens are identified by a locus notation and number, e.g., HLA-A11. The inheritance of certain HLA alleles is associated with increased risk for certain diseases (e.g., insulin-dependent diabetes mellitus).
Canadian Medical Guide Definition DNA Probes, HPV - DNA probes specific for the identification of human papilloma virus.

DNA Probes Medical Definitions and Terms

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