Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Proliferating Cell Nuclear Antigen Terms and Definitions

Proliferating Cell Nuclear Antigen

Medical Definition:	Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Guide Notes:	a nuclear protein; DF: note short X ref
Previously Indexed:	Nuclear Proteins (1988-1994),Nucleoproteins (1983-1987)

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