Canadian Medical Guide > Chemicals and Drugs > Organic Chemicals > Nitroso Compounds > Nitrosourea Compounds Terms and Definitions

Nitrosourea Compounds

Medical Definition:
Guide Notes:	DF: NITROSOUREA CPDS
Previously Indexed:	Nitroso Compounds (1966-1970),Urea (1966-1970)

Nitrosourea Compounds Categories.

	Carmustine - A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
	Ethylnitrosourea - A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
	Lomustine - An alkylating agent of value against both hematologic malignancies and solid tumors.
	Methylnitrosourea - A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
	Nimustine - Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
	Streptozocin - An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.

Nitrosourea Compounds Medical Definitions and Terms

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