Canadian Medical Guide > Chemicals and Drugs > Neurotransmitters and Neurotransmitter Agents > Neurotransmitter Agents > Neurotransmitter Uptake Inhibitors Terms and Definitions




Neurotransmitter Uptake Inhibitors

Medical Definition: Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.
Guide Notes: GEN or unspecified; prefer specific groups or specific drugs; coord IM with specific neurotransmitters /physiol (IM); DF: NEUROTRANSM UPTAKE INHIB
Previously Indexed: Cytoplasmic Granules (1966-1977),Kinetics (1966-1984),Nerve Endings (1966-1973),Synapses (1966-1971),Synaptic Vesicles (1972-1973),Synaptosomes (1974-1984)
Neurotransmitter Uptake Inhibitors Categories.
Canadian Medical Guide Definition Serotonin Uptake Inhibitors - Compounds that specifically inhibit the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. These agents have been used in treatment of depression, panic disorder, obsessive-compulsive behavior, and alcoholism, as analgesics, and to treat obesity and bulimia. Many of the ADRENERGIC UPTAKE INHIBITORS also inhibit serotonin uptake; they are not included here.

Neurotransmitter Uptake Inhibitors Medical Definitions and Terms

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