Canadian Medical Guide > Chemicals and Drugs > Neurotransmitters and Neurotransmitter Agents > Neurotransmitter Agents > GABA Agents Terms and Definitions

GABA Agents

Medical Definition:	Substances used for their pharmacological actions on GABAergic systems. GABAergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.
Guide Notes:	agents acting on GABAergic systems; GEN or unspecified; prefer specific groups or specific drugs
Previously Indexed:	GABA/pharmacology (1972-1994)

GABA Agents Categories.

	GABA Agonists - Drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA).
	GABA Antagonists - Drugs that bind to but do not activate GAMMA-AMINOBUTYRIC ACID receptors, thereby blocking the actions of endogenous GAMMA-AMINOBUTYRIC ACID or GAMMA-AMINOBUTYRIC ACID agonists.
	GABA Modulators - Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.

GABA Agents Medical Definitions and Terms

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