Canadian Medical Guide > Chemicals and Drugs > Polycyclic Hydrocarbons > Polycyclic Hydrocarbons, Aromatic > Naphthalenes > Lovastatin Terms and Definitions




Lovastatin

Medical Definition: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Guide Notes: /biosyn permitted if by fungus
Also Called: MK-803,Lovastatin, (1 alpha(S*))-Isomer,Lovastatin, 1 alpha-Isomer (without R*/S* notation),Mevacor
CAS Type 1 Name: CAS Number: 75330-75-5
Previously Indexed: Anticholesteremic Agents (1966-1987),Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors (1977-1987),Naphthalenes (1966-1987)
Lovastatin Categories.
Canadian Medical Guide Definition Simvastatin - A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL-cholesterol (LIPOPROTEINS, LDL CHOLESTEROL).

Lovastatin Medical Definitions and Terms

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