Canadian Medical Guide > Chemicals and Drugs > Organic Chemicals > Lactones > Macrolides > Sirolimus Terms and Definitions




Sirolimus

Medical Definition: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Also Called: AY 22-989,Rapamune
CAS Number: 53123-88-9
Previously Indexed: Polyenes (1976-1998)

Sirolimus Medical Definitions and Terms

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