Canadian Medical Guide > Diseases > Digestive System Diseases > Liver Diseases > Zellweger Syndrome Terms and Definitions

Zellweger Syndrome

Medical Definition:	An autosomal recessive peroxisomal disorder that typically presents in the neonatal period and is usually fatal. Clinical features include hypotonia, dysmorphic skull and facial bones, visual compromise, multifocal seizures, hepatomegaly, biliary dysgenesis, and swallowing difficulties. Pathologically, there are migration deficits of the neocortex and degeneration of white matter tracts. Zellweger-like syndrome refers to conditions that phenotypically resemble neonatal Zellweger syndrome, but occur in childhood or adulthood (From Adams et al., Principles of Neurology, 6th ed, p946)
Also Called:	Zellweger-Like Syndrome
Previously Indexed:	Abnormalities, Multiple (1968-1988),Brain Diseases (1966-1988),Kidney Diseases (1966-1988),Liver Diseases (1966-1988)

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