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Epitope Mapping - Methods used for studying the interactions of antibodies with specific regions of protein antigens. Important applications of epitope mapping are found within the area of immunochemistry. |
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Immunophenotyping - Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry. |
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Lymphocyte Activation - Morphologic alteration of small lymphocytes in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS, MITOGENS such as PHYTOHEMAGGLUTININS, and by specific antigens. It may also occur in vivo, as in GRAFT REJECTION and chronic myelogenous leukemia (LEUKEMIA, MYELOID, CHRONIC). |
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Rosette Formation - The in vitro formation of clusters consisting of a cell (usually a lymphocyte) surrounded by antigenic cells or antigen-bearing particles (usually erythrocytes, which may or may not be coated with antibody or antibody and complement). The rosette-forming cell may be an antibody-forming cell, a memory cell, a T-cell, a cell bearing surface cytophilic antibodies, or a monocyte possessing Fc receptors. Rosette formation can be used to identify specific populations of these cells. |
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Skin Window Technique |
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