Canadian Medical Guide > Analytical, Diagnostic and Therapeutic Techniques and Equipment > Investigative Techniques > Immunologic Techniques > Lymphocyte Activation Terms and Definitions

Lymphocyte Activation

Medical Definition:	Morphologic alteration of small lymphocytes in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS, MITOGENS such as PHYTOHEMAGGLUTININS, and by specific antigens. It may also occur in vivo, as in GRAFT REJECTION and chronic myelogenous leukemia (LEUKEMIA, MYELOID, CHRONIC).
Guide Notes:	lymphocyte transformation test goes here but do not index under specific agent inducing transformation unless particularly discussed; do not use for neoplastic or viral transformation of lymphocytes; DF: LYMPHOCYTE TRANSFORM
Previously Indexed:	Lymphocytes/immunology (1966-1968)

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