Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Heterocyclic Compounds, 2-Ring > Indoles Terms and Definitions

Indoles

Medical Definition:
Guide Notes:	includes isoindoles

Indoles Categories.

	Adrenochrome - Pigment obtained by the oxidation of epinephrine.
	Alcian Blue - A copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo.
	Captan - One of the phthalimide fungicides.
	Cytochalasins - A group of fungal metabolites that affect the motility of polymorphonuclear leukocytes.
	Gliotoxin - A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.
	Hydroxytryptophol - 5-Hydroxy-indole-3-ethanol.
	Indican - A substance occurring in the urine of mammals and also in blood plasma as the normal metabolite of tryptophan. An increased urinary excretion of indican is seen in Hartnup disease from the bacterial degradation of unabsorbed tryptophan.
	Indigotindisulfonate Sodium - An indolesulfonic acid that is used as a dye in renal function testing and as a reagent for the detection of nitrates and chlorates and in the testing of milk.
	Indocyanine Green - A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.
	Indomethacin - A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
	Isatin - An indole-dione that is obtained by oxidation of indigo blue. It is a MONOAMINE OXIDASE INHIBITOR and high levels have been found in urine of PARKINSONISM patients.
	Mazindol - Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
	Molindone - An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)
	Oxyphenisatin Acetate - A laxative that undergoes enterohepatic circulation. It may cause jaundice.
	Perindopril - An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.
	Skatole
	Sporidesmins - A group of related mycotoxins produced by the pasture fungus Pithomyces chartarum (formerly Sporidesmium bakeri); causes liver damage and facial eczema in cattle and sheep.

Indoles Medical Definitions and Terms

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