Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > GTP-Binding Protein Regulators > Guanine Nucleotide Exchange Factors Terms and Definitions

Guanine Nucleotide Exchange Factors

Medical Definition:	Protein factors that promote the exchange of GTP for GDP bound to GTP-BINDING PROTEINS.
Previously Indexed:	G-Proteins (1994-1999),Proteins (1978-1999)

Guanine Nucleotide Exchange Factors Categories.

	Eukaryotic Initiation Factor-2B - A guanine nucleotide exchange factor that acts to restore EUKARYOTIC INITIATION FACTOR-2 to its GTP bound form.
	Guanine Nucleotide-Releasing Factor 2 - A 145-kD guanine nucleotide exchange factor that is specific for rap1 and ras GTP-BINDING PROTEINS. It associates with SH3 domains of the crk family of signaling proteins.
	ral Guanine Nucleotide Exchange Factor - A guanine nucleotide exchange factor that stimulates the dissociation of GDP from RAL-GTP BINDING PROTEINS. It also has GDP exchange activity towards other MONOMERIC GTP-BINDING PROTEINS.
	ras Guanine Nucleotide Exchange Factors - A family of GUANINE NUCLEOTIDE EXCHANGE FACTORS that are specific for RAS PROTEINS.

Guanine Nucleotide Exchange Factors Medical Definitions and Terms

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