Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > GTP-Binding Protein Regulators > GTPase-Activating Proteins Terms and Definitions

GTPase-Activating Proteins

Medical Definition:	Proteins that activate the GTPase of specific GTP-BINDING PROTEINS.
Previously Indexed:	Proteins (1989-1999)

GTPase-Activating Proteins Categories.

	Chimerin Proteins - A family of GTPASE-ACTIVATING PROTEINS that are specific for RAC GTP-BINDING PROTEINS.
	Eukaryotic Initiation Factor-5 - A eukayotic initiation factor that interacts with the 40S initiation complex and promotes the hydrolysis of the bound GTP. The hydrolysis of GTP causes the release of EUKARYOTIC INITIATION FACTOR-2 and EUKARYOTIC INITIATION FACTOR-3 from the 40S subunit and the subsequent joining of the 60S ribosomal subunit to the 40S complex to form the functional 80S initiation complex
	ras GTPase-Activating Proteins - PROTEINS that specifically activate the GTP-phosphohydrolase activity of RAS PROTEINS.
	RGS Proteins - A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.

GTPase-Activating Proteins Medical Definitions and Terms

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