Canadian Medical Guide > Biological Sciences > Genetic Processes > DNA Repair Terms and Definitions




DNA Repair

Medical Definition: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Guide Notes: coord IM with specific DNA (IM)
Also Called: Base Excision Repair,Excision Repair,Nucleotide Excision Repair
Previously Indexed: DNA (1966-1970),DNA/biosynthesis (1966-1970)
DNA Repair Categories.
Canadian Medical Guide Definition SOS Response (Genetics) - An error-prone mechanism or set of functions for repairing damaged microbial DNA. SOS functions (a concept reputedly derived from the SOS of the international distress signal) are involved in DNA repair and mutagenesis, in cell division inhibition, in recovery of normal physiological conditions after DNA repair, and possibly in cell death when DNA damage is extensive.

DNA Repair Medical Definitions and Terms

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