Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Viral Regulatory Proteins Terms and Definitions

Viral Regulatory Proteins

Medical Definition:	Proteins which regulate the rate of transcription of viral structural genes.
Guide Notes:	IM; coord with specific virus (IM); /drug eff /ultrastruct permitted; DF: VIRAL REG PROTEINS
Previously Indexed:	Repressor Proteins (1979-1989),Transcription Factors (1977-1989),Viral Proteins (1972-1989)

Viral Regulatory Proteins Categories.

	Gene Products, nef - Products of the HIV nef gene (formerly 3'-orf gene). The products trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.
	Gene Products, rex - Post-transcriptional regulatory proteins required for the accumulation of mRNAs that encode the gag and env gene products in HUMAN T-LYMPHOTROPIC VIRUS 1 and HUMAN T-LYMPHOTROPIC VIRUS 2. The rex (regulator x; x is undefined) products act by binding to elements in the LTR.
	Gene Products, vif - A 23 kDa regulatory protein important for virion infectivity in HIV. The protein is found in the cytoplasm of HIV-infected cells and is not absolutely required for virion formation.
	Gene Products, vpu - Non-glycosylated, membrane-associated, 16 kDa proteins which are expressed in large amounts in cells infected with HIV-1. The proteins are required for efficient virion maturation and release. They are not present in HIV-2 nor in SIV. vpu is short for viral protein U, with U undefined.
	Immediate-Early Proteins - Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.
	Trans-Activators - Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

Viral Regulatory Proteins Medical Definitions and Terms

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