Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Transcription Factors, General Terms and Definitions




Transcription Factors, General

Medical Definition: Transcription factors that form transcription intiation complexes on DNA, bind to specific DNA-DIRECTED RNA POLYMERASES and are required to initiate transcription. Although their binding may be localized to distinct sequence and structural motifs within the DNA they are considered non-specific with regard to the specific gene being transcribed.
Also Called: General Transcription Initiation Complex Proteins
Transcription Factors, General Categories.
Canadian Medical Guide Definition Pol1 Transcription Initiation Complex Proteins - Factors that form a preinitiation complex at promoters that are specifically transcribed by RNA POLYMERASE I.
Canadian Medical Guide Definition TATA Box Binding Protein-Like Proteins - A class of proteins related in structure and function to TATA-BOX BINDING PROTEIN that can take the place of TATA-BOX BINDING PROTEIN in the transcription initiation complex. They are found in most multicellular organisms and may be involved in tissue-specific promoter regulation. They bind to DNA and interact with TATA-BINDING PROTEIN ASSOCIATED FACTORS, however they may lack specificity for the TATA-BOX.
Canadian Medical Guide Definition TATA-Binding Protein Associated Factors - Factors that associate with TATA-BOX BINDING FACTOR. Many of them are components of TRANSCRIPTION FACTOR TFIID
Canadian Medical Guide Definition TATA-Box Binding Protein - A general transcription factor that plays a major role in the activation of eukaryotic genes transcribed by RNA POLYMERASES. It binds specifically to the TATA BOX promoter element, which lies close to the position of transcription initiation in RNA transcribed by RNA POLYMERASE II. Although considered a principal component of TRANSCRIPTION FACTOR TFIID it also takes part in general transcription factor complexes involved in RNA POLYMERASE I and RNA POLYMERASE III transcription.
Canadian Medical Guide Definition Transcription Factors, TFII - The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.
Canadian Medical Guide Definition Transcription Factors, TFIII - Factors that bind to RNA POLYMERASE III and aid in transcription. They include the assembly factors TFIIIA and TFIIIC and the initiation factor TFIIIB. All combine to form a preinitiation complex at the promotor that directs the binding of RNA POLYMERASE III.

Transcription Factors, General Medical Definitions and Terms

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