Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Retinoblastoma Protein Terms and Definitions

Retinoblastoma Protein

Medical Definition:	Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
Guide Notes:	/biosyn /drug eff /physiol /ultrastruct permitted
Also Called:	p105-Rb Protein
Previously Indexed:	Phosphoproteins (1990)

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