Medical Definition: |
Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun. |
Guide Notes: |
/drug eff /ultrastruct permitted; DF: note short X refs |
Also Called: |
jun B Proteins,jun D Proteins |
Previously Indexed: |
DNA-Binding Proteins (1987-1991),Proto-Oncogene Proteins (1987-1991),Transcription Factors (1987-1991) |