Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > HMGA Proteins Terms and Definitions
HMGA Proteins
Medical Definition: | Proteins containing AT-HOOK MOTIFS that are rich in arginine and glycine residues. They bind to the minor grove of AT-rich regions of DNA. |
Previously Indexed: | Chromosomal Proteins, Non-Histone (1977-1984),High Mobility Group Proteins (1985-2001),Nucleoproteins (1966-1981) |
HMGA1a Protein - An 11 kD AT-hook motif-containing (AT-HOOK MOTIFS) protein that binds to the minor grove of AT-rich regions of DNA. It is the full-length product of the alternatively-spliced HMGA1 gene and may function as an architectural chromatin binding protein that is involved in transcriptional regulation. | |
HMGA1b Protein - An AT-hook motif-containing protein (AT-HOOK MOTIFS) that binds to the minor grove of AT-rich regions of DNA. It is a truncated form of HMGA1a protein that is produced by alternative-splicing of the HMGA1 gene. It may function as an architectural chromatin binding protein that is involved in transcriptional regulation. | |
HMGA1c Protein - An AT-hook-containing (AT-HOOK MOTIFS) nuclear protein that may be involved in retinoid-dependent transcriptional activity. | |
HMGA2 Protein - An AT-hook-containing (AT-HOOK MOTIFS) nuclear protein that is expressed predominantly in proliferating and undifferentiated mesenchymal cells. |
HMGA Proteins Medical Definitions and Terms
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