Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > CCAAT-Enhancer-Binding Proteins Terms and Definitions

CCAAT-Enhancer-Binding Proteins

Medical Definition:	A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
Guide Notes:	GEN: prefer specifics
Previously Indexed:	DNA-Binding Proteins (1991-2000),Nuclear Proteins (1991-2000)

CCAAT-Enhancer-Binding Proteins Categories.

	CCAAT-Binding Factor - A heterotrimeric DNA-binding protein that binds to CCAAT motifs in the promoters of eukaryotic genes. It is composed of three subunits: A, B and C.
	CCAAT-Enhancer-Binding Protein-alpha - A CCAAT-enhancer-binding protein found in LIVER; ADIPOSE TISSUE; INTESTINES; LUNG; ADRENAL GLANDS; PLACENTA; OVARY and peripheral blood mononuclear cells (LEUKOCYTES, MONONUCLEAR). Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES.
	CCAAT-Enhancer-Binding Protein-beta - A CCAAT-enhancer-binding protein found in LIVER; INTESTINES; LUNG and ADIPOSE TISSUE. It is an important mediator of INTERLEUKIN-6 signaling.

CCAAT-Enhancer-Binding Proteins Medical Definitions and Terms

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