Medical Definition: |
A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation. |
Guide Notes: |
PC stands for PheochromoCytoma; almost always NIM with no subheadings; check ANIMAL; & RATS; do not routinely add PHEOCHROMOCYTOMA or ADRENAL GLAND NEOPLASMS |
Previously Indexed: |
Cell Line (1976-1991),Clone Cells (1977-1987),Tumor Cells, Cultured (1987-1991) |