Canadian Medical Guide > Anatomy > Cells > Cells, Cultured > Cell Line > Cell Line, Tumor Terms and Definitions




Cell Line, Tumor

Medical Definition: A cell line derived from cultured tumor cells.
Guide Notes: almost always NIM with no subheadings; check ANIMALS or HUMAN; do not routinely add neoplasm term; policy Manual 21.57, 22.26.1, 24.4.5
Previously Indexed: Cell Line (1969-1989),Tumor Cells, Cultured (1988-2003)
Cell Line, Tumor Categories.
Canadian Medical Guide Definition Caco-2 Cells - Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.
Canadian Medical Guide Definition HCT116 Cells - Human COLORECTAL CARCINOMA cell line.
Canadian Medical Guide Definition Hela Cells - The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks (one of several pseudonyms). These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Canadian Medical Guide Definition HL-60 Cells - A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Canadian Medical Guide Definition HT29 Cells - Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.
Canadian Medical Guide Definition Jurkat Cells - A CELL LINE derived from human T-CELL LEUKEMIA and used to determine the mechanism of differential susceptibility to anti-cancer drugs and radiation.
Canadian Medical Guide Definition K562 Cells - An ERYTHROLEUKEMIA cell line derived from a CHRONIC MYELOID LEUKEMIA patient in BLAST CRISIS.
Canadian Medical Guide Definition PC12 Cells - A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.
Canadian Medical Guide Definition U937 Cells - A human cell line established from a diffuse histiocytic lymphoma (HISTIOCYTIC LYMPHOMA, DIFFUSE) and displaying many monocytic characteristics. It serves as an in vitro model for MONOCYTE and MACROPHAGE differentiation.

Cell Line, Tumor Medical Definitions and Terms

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