Canadian Medical Guide > Chemicals and Drugs > Organic Chemicals > Amides > Acetamides > 2-Acetylaminofluorene Terms and Definitions




2-Acetylaminofluorene

Medical Definition: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the arylhydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
Guide Notes: D25-26 qualif
Also Called: Acetylaminofluorene
CAS Type 1 Name: CAS Number: 53-96-3
Previously Indexed: Acetamides (1971-1974),Fluorenes (1966-1974)
2-Acetylaminofluorene Categories.
Canadian Medical Guide Definition Acetoxyacetylaminofluorene - An alkylating agent that forms DNA ADDUCTS at the C-8 position in GUANINE, resulting in single strand breaks. It has demonstrated carcinogenic action.
Canadian Medical Guide Definition Hydroxyacetylaminofluorene - A N-hydroxylated derivative of 2-ACETYLAMINOFLUORENE that has demonstrated carcinogenic action.

2-Acetylaminofluorene Medical Definitions and Terms

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