Canadian Medical Guide > Diseases > Cardiovascular Diseases > Vascular Diseases > Vascular Hemostatic Disorders Terms and Definitions

Vascular Hemostatic Disorders

Medical Definition:

Alterations in the mechanical integrity or structure of the blood vessels leading to bleeding disorders.

Vascular Hemostatic Disorders Categories.

	Cryoglobulinemia - A condition characterized by the presence of abnormal or abnormal quantities of cryoglobulins in the blood. They are precipitated into the microvasculature on exposure to cold and cause restricted blood flow in exposed areas.
	Cushing Syndrome - A condition, more commonly seen in females, due to hyperadrenocorticism resulting from neoplasms of the adrenal cortex or the anterior lobe of the pituitary, or to prolonged excessive intake of glucocorticoids for therapeutic purposes. The symptoms and signs may include rapidly developing adiposity of the face, neck, and trunk, kyphosis caused by osteoporosis of the spine, hypertension, diabetes mellitus, amenorrhea, hypertrichosis in females, impotence in males, dusky complexion with purple markings, polycythemia, pain in the abdomen and back, and muscular wasting and weakness. When secondary to excessive pituitary secretion of adrenocorticotropin, it is known as Cushing's disease. (Dorland, 27th ed)
	Ehlers-Danlos Syndrome - A heterogeneous group of inherited COLLAGEN DISEASES. The most common manifestations of Ehlers-Danlos Syndrome are hyperextensible skin and joints, skin fragility and reduced wound healing capability.
	Pseudoxanthoma Elasticum - A rare, progressive inherited disorder resulting from extensive basophilic degeneration of elastic tissue, usually presenting after puberty and involving the skin, eye, and cardiovascular system. Characteristic manifestations are small, circumscribed yellowish patches at sites of considerable movement of the skin, ANGIOID STREAKS in the retina, and a tendency towards hemorrhage and arterial insufficiency.
	Purpura, Hyperglobulinemic - Purpura seen in many hematological disorders, characterized by an increase in GAMMA-GLOBULINS.
	Purpura, Schoenlein-Henoch - A form of nonthrombocytopenic purpura due to a hypersensitivity vasculitis associated with a variety of clinical symptoms including urticaria and erythema, arthropathy and arthritis, gastrointestinal symptoms, and renal involvement.
	Scurvy - A condition due to deficiency of ASCORBIC ACID (vitamin C) in the diet and marked by weakness, anemia, spongy gums, a tendency to mucocutaneous hemorrhages and a brawny induration of the muscles of the calves and legs. (Dorland, 27th ed)
	Shwartzman Phenomenon - A vasculitis, local or systemic, caused by a two-stage reaction in which a first encounter with endotoxin produces intravascular fibrin thrombi whose clearance results in reticuloendothelial blockade which prevents the clearance of thrombi caused by a second encounter with endotoxin, (or a variety of polyanions, glycogen or antigen/antibody complexes) resulting in tissue necrosis and/or hemorrhage. In pregnancy gram-negative septicemia during delivery or abortion may serve as the first or provocative encounter.
	Waldenstrom Macroglobulinemia - A plasma cell dyscrasia resembling leukemia with cells of lymphocytic, plasmacytic, or intermediate morphology, which secrete an IMMUNOGLOBULIN M monoclonal component. There is diffuse infiltration of bone marrow and also, in many cases, of the spleen, liver, or lymph nodes. The circulating macroglobulin produces symptoms of hyperviscosity syndrome: weakness, fatigue, bleeding disorders, and visual disturbances. Peak incidence is in the sixth and seventh decades. (Dorland, 28th ed)

Vascular Hemostatic Disorders Medical Definitions and Terms

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