Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > Ubiquitins > Ubiquitin Terms and Definitions




Ubiquitin

Medical Definition: A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
Guide Notes: UBIQUITINS
Also Called: Ubiquitin, Human
Previously Indexed: Chromosomal Proteins, Non-Histone (1977-1984),Nucleoproteins (1966-1977),Peptides (1975-1980),Ubiquitins (1985-2001)
Ubiquitin Categories.
Canadian Medical Guide Definition Polyubiquitin - An oligomer formed from the repetitive linking of the C-terminal glycine of one UBIQUITIN molecule via an isopeptide bond to a lysine residue on a second ubiquitin molecule. It is structurally distinct from UBIQUITIN C, which is a single protein containing a tandemly arrayed ubiquitin peptide sequence.
Canadian Medical Guide Definition Ubiquitin C - A single protein comprised of tandem repeats of the UBIQUITIN 78 amino acid sequence. It is a product of the polyubiquitin gene which contains multiple copies of the ubiquitin coding sequence. Proteolytic processing of ubiquitin C results in the formation of individual ubiquitin molecules. This protein is distinct from POLYUBIQUITIN, which is a protein formed through isopeptide linkage of multiple ubiquitin species.

Ubiquitin Medical Definitions and Terms

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