Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > Tissue Inhibitor of Metalloproteinases > Tissue Inhibitor-of Metalloproteinase-2 Terms and Definitions

Tissue Inhibitor-of Metalloproteinase-2

Medical Definition:	A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21 kD nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
Guide Notes:	DF: note short X ref
CAS Number:	127497-59-0
Previously Indexed:	Neoplasm Proteins (1989-1993),Proteins (1990-1997)

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