Canadian Medical Guide > Chemicals and Drugs > Organic Chemicals > Hydrocarbons > Terpenes > Sesquiterpenes Terms and Definitions

Sesquiterpenes

Medical Definition:
Guide Notes:	GEN; prefer specifics

Sesquiterpenes Categories.

	Artemisinins - A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).
	Gossypol - A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
	Santonin - Anthelminic isolated from the dried unexpanded flower heads of Artemisia maritima and other species of Artemisia found principally in Russian and Chinese Turkestan and the Southern Ural region. (From Merck, 11th ed.)
	Sesquiterpenes, Eudesmane - SESQUITERPENES cyclized into two adjoining cyclohexane rings but with a different configuration from the ARTEMISININS.
	Sesquiterpenes, Germacrane - SESQUITERPENES cyclized to one 10-carbon ring.
	Sesquiterpenes, Guaiane - SESQUITERPENES cyclized into two adjoining rings, one being 7-carbons and the other is 5-carbons.
	Thapsigargin - A potent skin irritating sesquiterpene lactone isolated from the roots of Thapsia garganica L. (Apiaceae). It also acts as a non-phorbol-ester-type tumor promoter which discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca(2+)-ATPase. (Biochem Pharmacol 1987;36(5):621-6; Proc Natl Acad Sci USA 1991;88(16):7096-100)
	Trichothecenes - Usually 12,13-epoxytrichothecenes, produced by Fusaria, Stachybotrys, Trichoderma and other fungi, and some higher plants. They may contaminate food or feed grains, induce emesis and hemorrhage in lungs and brain, and damage bone marrow due to protein and DNA synthesis inhibition.

Sesquiterpenes Medical Definitions and Terms

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