Canadian Medical Guide > Chemicals and Drugs > Organic Chemicals > Hydrocarbons > Terpenes > Diterpenes Terms and Definitions

Diterpenes

Medical Definition:	Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.
Guide Notes:	GEN; prefer specifics
Also Called:	Diterpenes, Cembrane,Diterpenes, Labdane,Norditerpenes

Diterpenes Categories.

	Aphidicolin - An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.
	Atractyloside - A glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due to inhibition of ADENINE NUCLEOTIDE TRANSLOCASE.
	Diterpenes, Abietane - A group of DITERPENES cyclized into 3-ring PHENANTHRENES.
	Diterpenes, Clerodane - A group of DITERPENES cyclized into 2-rings with a side-chain.
	Diterpenes, Kaurane - A group of DITERPENES cyclized into four rings.
	Forskolin - Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive ionotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
	Gibberellins - A class of plant growth hormone isolated from cultures of Gibberella fujikuroi, a fungus causing Bakanae disease in rice. There are many different members of the family as well as mixtures of multiple members; all are diterpenoid acids based on the gibberellane skeleton.
	Phorbols - The parent alcohol of the tumor promoting compounds from CROTON OIL (Croton tiglium).
	Phytanic Acid - A 20-carbon branched chain fatty acid. In phytanic acid storage disease (REFSUM DISEASE) this lipid may comprise as much as 30% of the total fatty acids of the plasma. This is due to a phytanic acid alpha-hydroxylase deficiency.
	Phytol

Diterpenes Medical Definitions and Terms

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