Canadian Medical Guide > Diseases > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Genetic Diseases, Inborn > Metabolism, Inborn Errors > Steroid Metabolism, Inborn Errors > Mineralocorticoid Excess Syndrome, Apparent Terms and Definitions
Mineralocorticoid Excess Syndrome, Apparent
Medical Definition: | A hereditary disease characterized by childhood onset HYPERTENSION, hypokalemic alkalosis, and low RENIN and ALDOSTERONE secretion. It results from a defect in the activity of the 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 enzyme which results in inadequate conversion of CORTISOL to CORTISONE. The build up of unprocessed cortisol to levels that stimulate MINERALOCORTICOID RECEPTORS creates the appearance of having excessive MINERALOCORTICOIDS. |
Previously Indexed: | Metabolism, Inborn Errors (1977-2003) |
Mineralocorticoid Excess Syndrome, Apparent Medical Definitions and Terms
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