Canadian Medical Guide > Diseases > Congenital, Hereditary, and Neonatal Diseases and Abnormalities > Genetic Diseases, Inborn > Skin Diseases, Genetic > Keratoderma, Palmoplantar Terms and Definitions




Keratoderma, Palmoplantar

Medical Definition: Group of mostly hereditary disorders characterized by thickening of the palms and soles as a result of excessive keratin formation leading to hypertrophy of the stratum corneum (hyperkeratosis).
Guide Notes: do not confuse with KERATODERMA, PALMOPLANTAR, DIFFUSE or with POROKERATOSIS PALMARIS ET PLANTARIS see POROKERATOSIS; note X-ref HYPERKERATOSIS PALMARIS ET PLANTARIS
Also Called: Meleda Disease
Keratoderma, Palmoplantar Categories.
Canadian Medical Guide Definition Keratoderma, Palmoplantar, Diffuse - An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present.
Canadian Medical Guide Definition Papillon-Lefevre Disease - Rare, autosomal recessive disorder occurring between the first and fifth years of life. It is characterized by palmoplantar keratoderma with periodontitis followed by the premature shedding of both deciduous and permanent teeth.

Keratoderma, Palmoplantar Medical Definitions and Terms

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