Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > Receptors, Cytoplasmic and Nuclear > Receptors, Steroid Terms and Definitions




Receptors, Steroid

Medical Definition: Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.
Guide Notes: GEN; prefer specifics; coord IM with specific steroid (IM); DF: RECEPT STEROID
Also Called: Receptors, Corticosteroid
Previously Indexed: Receptors, Cell Surface (1973-1976),Receptors, Drug (1968-1972),Steroids (1966-1976)
Receptors, Steroid Categories.
Canadian Medical Guide Definition Receptors, Androgen - Proteins, generally found in the cytoplasm, that specifically bind androgens and mediate their cellular actions. The complex of the androgen and receptor migrates to the nucleus where it induces transcription of specific segments of DNA.
Canadian Medical Guide Definition Receptors, Calcitriol - Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA. Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
Canadian Medical Guide Definition Receptors, Estrogen - Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Canadian Medical Guide Definition Receptors, Glucocorticoid - Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.
Canadian Medical Guide Definition Receptors, Mineralocorticoid - Cytoplasmic proteins that specifically bind mineralocorticoids and mediate their cellular effects. The receptor with its bound ligand acts in the nucleus to induce transcription of specific segments of DNA. Mineralocorticoids were named for their actions on extracellular electrolyte concentrations. The most important example is aldosterone.
Canadian Medical Guide Definition Receptors, Progesterone - Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.

Receptors, Steroid Medical Definitions and Terms

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