Canadian Medical Guide > Chemicals and Drugs > Heterocyclic Compounds > Heterocyclic Compounds, 2-Ring > Quinolines > Quinolones Terms and Definitions

Quinolones

Medical Definition:	A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.
Guide Notes:	do not confuse with QUINOLINES
Previously Indexed:	Quinolines (1966-1988)

Quinolones Categories.

	4-Quinolones - QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinoloines are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.
	Fluoroquinolones - A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.
	PQQ Cofactor - A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES.

Quinolones Medical Definitions and Terms

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