Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Proteins > Cytoskeletal Proteins Terms and Definitions

Cytoskeletal Proteins

Medical Definition:	Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.
Guide Notes:	/biosyn /drug eff /physiol permitted; do not use /analogs
Previously Indexed:	Cytoplasm (1966-1979),Cytoskeleton (1977-1984),Proteins or specific proteins (1966-1984)

Cytoskeletal Proteins Categories.

	Adenomatous Polyposis Coli Protein - A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.
	Intermediate Filament Proteins - Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.
	Microfilament Proteins - Filaments which are composed primarily of actin and found in the cytoplasmic matrix of almost all cells. They are often associated with microtubules and may play a role in cytoskeletal function and/or mediate movement of the cell or the organelles within the cell.
	Microtubule Proteins - Proteins found in the microtubules.
	Talin - A 235-kDa cytoplasmic protein that is also found in platelets. It has been localized to regions of cell-substrate adhesion. It binds to INTEGRINS; VINCULIN; and ACTINS and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton.
	Vinculin - A cytoskeletal protein associated with cell-cell and cell-matrix interactions. The amino acid sequence of human vinculin has been determined. The protein consists of 1066 amino acid residues and its gene has been assigned to chromosome 10.

Cytoskeletal Proteins Medical Definitions and Terms

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