Canadian Medical Guide > Diseases > Nervous System Diseases > Autoimmune Diseases of the Nervous System > Polyradiculoneuropathy > Guillain-Barre Syndrome Terms and Definitions




Guillain-Barre Syndrome

Medical Definition: An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)
Guide Notes: do not confuse X ref POLYRADICULONEUROPATHY ACUTE, INFLAMMATORY with POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY see POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING
Previously Indexed: Polyradiculoneuropathy (1966-1999)
Guillain-Barre Syndrome Categories.
Canadian Medical Guide Definition Miller Fisher Syndrome - A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)

Guillain-Barre Syndrome Medical Definitions and Terms

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