Canadian Medical Guide > Chemicals and Drugs > Amino Acids, Peptides, and Proteins > Peptides > Peptides, Cyclic > Streptogramins Terms and Definitions

Streptogramins

Medical Definition:	A class of natural cyclic peptide antibiotics produced by certain subspecies of STREPTOMYCES. They include two structurally unrelated components, STREPTOGRAMIN GROUP A and STREPTOGRAMIN GROUP B, which generally act synergistically to inhibit bacterial growth.
Previously Indexed:	Virginiamycin (1992-2001)

Streptogramins Categories.

	Mikamycin - An antibiotic complex originally isolated from Streptomyces mitakaenis. It contains two principle ingredients: mikamycin A (STREPTOGRAMIN A) and mikamycin B (STREPTOGRAMIN B)
	Pristinamycin - An antibiotic mixture originally isolated from Streptomyces pristinaspiralis. It is a mixture of compounds from STREPTOGRAMIN GROUP A: pristinamycin IIA and IIB(STREPTOGRAMIN A) and from STREPTOGRAMIN GROUP B: pristinamycin IA(STREPTOGRAMIN B), pristinamycin IB, pristinamycin IC.
	Streptogramin Group A - A structural subclass of streptogramins that includes molecules containing unsaturated macrocyclic lactones with approximate molecular weight of 500 KD.
	Streptogramin Group B - A structural subclass of streptogramins. They are cyclic hexadepsipeptides with approximate molecular weight of 800 that contain a characteristic 3-hydroxy picolinoyl exocyclic component.
	Vernamycin B - An antibiotic mixture originally isolated from Streptomyces loidensis. It contains a mixture of compounds belonging to STREPTOGRAMIN GROUP A and STREPTOGRAMIN GROUP B.
	Virginiamycin - A cyclic polypeptide antibiotic complex from Streptomyces virginiae, S. loidensis, S. mitakaensis, S. pristina-spiralis, S. ostreogriseus, and others. It consists of 2 major components, virginiamycin Factor M1(STREPTOGRAMIN A) and virginiamycin Factor S1. It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine, and poultry.

Streptogramins Medical Definitions and Terms

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